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    • Brief Report: The Genetic Profile of Rheumatoid Factor–Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis 

      Hinks, Anne; Marion, Miranda C.; Cobb, Joanna; Comeau, Mary E.; Sudman, Marc; Ainsworth, Hannah C.; Bowes, John; Becker, Mara L.; Bohnsack, John F.; Haas, Johannes-Peter; Lovell, Daniel J.; Mellins, Elizabeth D.; Nelson, J. Lee; Nordal, Ellen Berit; Punaro, Marilynn; Reed, Ann M.; Rose, Carlos D.; Rosenberg, Alan M.; Rygg, Marite; Smith, Samantha L.; Stevens, Anne M.; Videm, Vibeke; Wallace, Carol A.; Wedderburn, Lucy R.; Yarwood, Annie; Yeung, Rae S.M.; Langefeld, Carl D.; Thompson, Susan D.; Thomson, Wendy; Prahalad, Sampath (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-09)
      <i><p>Objective</i>: Juvenile idiopathic arthritis (JIA) comprises 7 heterogeneous categories of chronic childhood arthritides. Approximately 5% of children with JIA have rheumatoid factor (RF)–positive arthritis, which phenotypically resembles adult rheumatoid arthritis (RA). Our objective was to compare and contrast the genetics of RF‐positive polyarticular JIA with those of RA and selected other ...

    • Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases 

      Hinks, A; Bowes, J; Cobb, J; Ainsworth, HC; Marion, MC; Comeau, ME; Sudman, M; Han, B; Becker, ML; Bohnsack, JF; de Bakker, PIW; Haas, JP; Hazen, M; Lovell, DJ; Nigrovic, PA; Nordal, Ellen Berit; Punnaro, M; Rosenberg, AM; Rygg, Marite; Smith, S.L.; Wise, CA; Videm, Vibeke; Wedderburn, LR; Yarwood, A; Yeung, RSM; Prahalad, S; Langefeld, CD; Raychaudhuri, S; Thompson, SD; Thomson, W (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-20)
      Objectives: Juvenile idiopathic arthritis ( JIA) is a heterogeneous group of diseases, comprising seven categories. Genetic data could potentially be used to help redefine JIA categories and improve the current classification system. The human leucocyte antigen (HLA) region is strongly associated with JIA. Fine-mapping of the region was performed to look for similarities and differences in ...

    • Identification of a regulatory pathway governing TRAF1 via an arthritis-associated non-coding variant 

      Wang, Qiang; Martínez-Bonet, Marta; Kim, Taehyeung; Sparks, Jeffrey A.; Ishigaki, Kazuyoshi; Chen, Xiaoting; Sudman, Marc; Aguiar, Vitor; Sim, Sangwan; Hernandez, Marcos Chiñas; Chiu, Darren J.; Wactor, Alexandra; Wauford, Brian; Marion, Miranda C.; Gutierrez-Arcelus, Maria; Bowes, John; Eyre, Stephen; Nordal, Ellen Berit; Prahalad, Sampath; Rygg, Marite; Videm, Vibeke; Raychaudhuri, Soumya; Weirauch, Matthew T.; Langefeld, Carl D.; Thompson, Susan D.; Nigrovic, Peter A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-16)
      TRAF1/C5 was among the first loci shown to confer risk for inflammatory arthritis in the absence of an associated coding variant, but its genetic mechanism remains undefined. Using Immunochip data from 3,939 patients with juvenile idiopathic arthritis (JIA) and 14,412 control individuals, we identified 132 plausible common non-coding variants, reduced serially by single-nucleotide polymorphism ...